Based on the downregulation of TCA-related enzymes (such as PDHA1) and glycolysis-related enzymes (such as ALDOA) in the AMS-resistant group, Lu et al.15 reported that the TCA cycle and glycolysis are reduced in individuals without AMS but not in individuals with AMS after exposure to high altitude. The gene discussed is PDHA1; the disease is ablepharon macrostomia syndrome.