The AUC of the protection model with 5 proteins (ISLR2, MYOC, WFIKKN1, SCARA5, and ADAM15) that distinguished nAMS1k and nAMS4k was 0.95 (p value < 0.001, Fig. 3d), which indicated that these proteins may be involved in attenuating the symptoms of AMS in individuals without AMS at high altitudes. Here, WFIKKN1 is linked to ablepharon macrostomia syndrome.