Moreover, rather than clinical indexes, proteins, including FGF23, RET, IL18R1, and GNA14, were positively correlated with AMS symptom phenotypes, such as poor appetite, dyspnea, and lip cyanosis, between the AMS4k and nAMS4k groups (Supplementary Fig. 11b). This evidence concerns the gene IL18R1 and ablepharon macrostomia syndrome.