The AUC of the diagnosis model distinguishing AMS4k and nAMS4k with 13 proteins (TRAF2, angiotensinogen (AGT), IL18R1, Thy-1 cell surface antigen (THY1), ISLR2, transcobalamin 2 (TCN2), CD38, G protein subunit alpha 14 (GNA14), INHBC, GC, RBKS, WFIKKN1, and ARF6) was 0.89 (p value < 0.01, Fig. 3f), which indicated the potential translational value of these proteins as diagnostic biomarkers of AMS. The gene discussed is WFIKKN1; the disease is ablepharon macrostomia syndrome.