GRP and ablepharon macrostomia syndrome: In addition, C-peptide, creatine kinase-MB (CKMB), estradiol-E2 (E2), phosphate, progastrin-releasing peptide (proGRP), procalcitonin, thyroglobulin, and thyroxine showed significant differences between the AMS4k and AMS1k groups but not between the nAMS4k and nAMS1k groups, which reveals that these clinical indexes are affected by AMS (Fig. 3b).