Furthermore, S100A12, SLC4A1, IGFBP7, APOB, A-TPO, phosphate, and cholesterol were correlated with multiple symptom phenotypes, such as fatigue, nausea, vomiting, and poor appetite (C2 in Fig. 5), which indicates their potential important roles in the development of AMS. The gene discussed is TPO; the disease is ablepharon macrostomia syndrome.