Furthermore, S100A12, SLC4A1, IGFBP7, APOB, A-TPO, phosphate, and cholesterol were correlated with multiple symptom phenotypes, such as fatigue, nausea, vomiting, and poor appetite (C2 in Fig. 5), which indicates their potential important roles in the development of AMS. Here, IGFBP7 is linked to ablepharon macrostomia syndrome.