Taken together, CRF1-expressing mPFC neurons (mPFCCRF1+) have the molecular components to respond to neurochemical stress signals, that are vulnerable to repeated ethanol exposure, and are also wired to mediate anxiety-like behaviors; therefore, mPFCCRF1+ neurons are poised to promote relapse to ethanol use during abstinence. Here, CRHR1 is linked to Anxiety.