Functionally, injection of CRF or CRF1 antagonists in the mPFC is anxiogenic and anxiolytic, respectively [22–25], deletion of forebrain CRF1 reduces anxiety [26], mPFC CRF-CRF1 underlies stress-induced executive dysfunction [27, 28], mPFC CRF signaling impairs working memory [29, 30], and mPFC CRF interneurons regulate behavioral selection during stress [31]. The gene discussed is CRHR1; the disease is Anxiety.