CXCL8 and allergic rhinitis: Secreted chemokines such as interleukin-8 (IL8) and monocyte chemotactic protein-1 (MCP-1) as well as cytokines such as tumor necrosis factor alfa (TNF-α) and IL-2 are responsible for the recruitment of granulocytes from the bloodstream to the lung tissue [27], which is a hallmark of an early innate immune response after subjects with asthma or seasonal allergic rhinitis were exposed to allergens [28–30].