MYC and acute myeloid leukemia: To test whether nuclear HK2 is required for AML stem and progenitor cell function, we selectively increased HK2 in the nucleus by expressing HK2 tagged with a c-Myc (NLS1, PAAKRVKLD) or SV40 (NLS2, PKKKRKV) nuclear localizing signal15 (NLS; Extended Data Fig. 2a).