As documented in Figs. 2C, D, S2-C, D, experimental results revealed that GIST-T1 cell viability and colony formation ability were declined by treatment with sh-NC + LLY-507, sh-EZH2 + LLY-507, sh-NC + AZ-505, or sh-EZH2 + AZ-505, especially treatment with sh-EZH2 + LLY-507 or sh-EZH2 + AZ-505. The gene discussed is EZH2; the disease is gastrointestinal stromal tumor.