In addition, sh-EZH2 + LLY-507 or sh-EZH2 + AZ-505 treatment led to enhancement of GIST-T1 cell senescence and G1 phase-arrested cells in contrast to sh-NC + LLY-507 or sh-NC + AZ-505 treatment (Figs. 2E, F, S2-E, F). Here, EZH2 is linked to gastrointestinal stromal tumor.