Meanwhile, EZH2 expression was increased in human GIST cell lines GIST-T1, GIST-48, and GIST-882 compared with GES-1 cell line, of which GIST-T1 cell line had the highest expression of EZH2 (Fig. S1) and was thus selected for subsequent experiments. The gene discussed is EZH2; the disease is gastrointestinal stromal tumor.