To verify the specific relationship between SMYD2, EZH2, and TET1 in GIST, the expression of SMYD2, EZH2, and TET1 was first detected in the tumor tissues collected from GIST patients with low risk, intermediate risk, and high risk using immunohistochemistry (Fig. 5A). This evidence concerns the gene TET1 and gastrointestinal stromal tumor.