Consistent with these results, the expression of EphA2, as well as Ephexin1 and EGFR, was aberrantly upregulated in lung cancer cell lines compared to normal human primary lung fibroblasts (Fig. 1e) and was also much higher in colorectal cancer cell lines than normal human colon cells (Supplementary Fig. S1d). This evidence concerns the gene NGEF and colorectal cancer.