Bao et al. then reported that RASAL2 had the same biological effect on autophagy in triple-negative and ER-positive breast cancer cells and that glucose starvation induced RASAL2 phosphorylation at S351, transforming its function from an inhibitor to an activator of AMPK-mediated autophagy, which in turn affected tumour progression [26]. Here, RASAL2 is linked to neoplasm.