While the intracellular tumor-promoting effect of PTENα is enhanced by the increased protein stability of PTENα resulted from the decreased expression of E3 ligase FBXW11 and increased expression of deubiquitinase USP9X as we previously reported [15], the extracellular tumor-suppressive role of PTENα was attenuated by the reduced generation of FragC. This evidence concerns the gene FBXW11 and neoplasm.