However, we reported that both PTENα and PTENβ (PTENα/β) manifest prominent nuclear localization due to the presence of a canonical nuclear localization signal in their NTEs, and exert tumor-promoting roles in liver cancer cells through the direct interaction of their NTEs with the histone H3 lysine 4 (H3K4) presenter WDR5 in the nucleus to promote H3K4 trimethylation and maintain a tumor-promoting signature [15]. Here, WDR5 is linked to neoplasm.