Moreover, although Zeb2 is also critical for short-lived effector cell (SLEC) function in acute viral infection (Dominguez et al, 2015; Omilusik et al, 2015; Guan et al, 2018), Zeb2 activity was predicted to occur at intermediate levels in recently activated, progenitor, and effector CD8 T cells in the islets. This evidence concerns the gene CD8A and viral infectious disease.