Increased TCR signaling has also been shown to impact cell fate by promoting effector function in acute LCMV infection and a RIP-OVA model of T1D (King et al, 2012), so we examined the phenotypic distributions of islet IGRP206-214–reactive CD8 T cells expressing each major TCR β J gene. The gene discussed is CD8A; the disease is type 1 diabetes mellitus.