Additionally, the DR can be improved, and the false positive rate can decrease by including other markers, such as as nasal bone, ductus venosus, tricuspid valve, and placental growth factor (PlGF).3, 6, 7, 8, 9, 10With further benefits of early prediction of other complications such as preeclampsia, intrauterine growth restriction (IUGR), and other anatomical malformations.6, 9. This evidence concerns the gene PGF and preeclampsia.