While our screen hits demonstrate the important role of H2O2 scavenging in combating β-Lapachone cytotoxicity, we also uncovered a surprising role for mitochondrial SOD2 in protection against cell death in both NRF2/KEAP1WT and NRF2/KEAP1MUT NSCLC cells. This evidence concerns the gene SOD2 and non-small cell lung carcinoma.