Further, in agreement with our previous report demonstrating that inhibition of glutathione synthesis does not sensitize NSCLC cells to β-Lapachone [25], there was a lack of glutathione-dependent enzymes in the hit list, and only small fold-changes for the glutathione synthesis enzymes GCLM and GCLC (Supplementary Table 1). Here, GCLC is linked to non-small cell lung carcinoma.