Similarly, mutations in Tgfβ2 and Tgfβr1 cause microretrognathia in Loeys-Dietz syndrome (Loeys et al., 2005; Zhao et al., 2008), mutations in Tgfβr2 and Smad2 cause jaw length defects (Nomura and Li, 1998; Oka et al., 2007; Oka et al., 2008), and TGFβ signaling has been shown to be essential for patterning the proximal portion of the murine dentary (Anthwal et al., 2008). This evidence concerns the gene TGFB1 and Loeys-Dietz syndrome.