Examples include the process of palatogenesis where TGFβ signaling and the regulation of MMPs are critical for shelf closure (Brunet et al., 1995; Proetzel et al., 1995; Chai et al., 1997; Kaartinen et al., 1997; Blavier et al., 2001; Ito et al., 2003; Dudas et al., 2006; Iwata et al., 2011), the pathogenesis of Marfan syndrome where elevated TGFβ signaling causes excessive upper jaw growth (Westling et al., 1998; Neptune et al., 2003), and the dysregulation of non-canonical NCM-mediated TGFβ signaling, which results in hypoplastic facial features (Yumoto et al., 2013). This evidence concerns the gene CWC22 and Marfan syndrome.