TGFBR1 and Loeys-Dietz syndrome: Similarly, mutations in Tgfβ2 and Tgfβr1 cause microretrognathia in Loeys-Dietz syndrome (Loeys et al., 2005; Zhao et al., 2008), mutations in Tgfβr2 and Smad2 cause jaw length defects (Nomura and Li, 1998; Oka et al., 2007; Oka et al., 2008), and TGFβ signaling has been shown to be essential for patterning the proximal portion of the murine dentary (Anthwal et al., 2008).