Our previous [4, 18] and more recent works unambiguously identify tumor-associated Thomsen-Friedenreich antigen and endothelium expressed Galectin-3 and α3β1 integrin involvement in cancer cell-EC adhesion [22, 23] and induction of focal adhesion type macromolecular signaling complex formation downstream of these interactions [22]. The gene discussed is LGALS3; the disease is cancer.