For example, Haddad et al. using human umbilical vein endothelial cells (HUVECs) demonstrated that after tumor cell coculturing with HUVECs for 5 hours, an increase in endothelial ICAM-1 (Inter Cellular Adhesion Molecule-1), VCAM-1 (Vascular Adhesion Molecule-1) and E-selectin is observed [44]. The gene discussed is ICAM1; the disease is neoplasm.