The potential increased GPR55 expression supports the development of GPR55 inhibitors to treat TS and suggests that a drug combination of ∆9-THC with potent GPR55 inhibitors such as tetrahydrocannabivarin (THCV) and cannabidivarin (CBDV) [7, 31, 62] may provide a more efficacious combination of cannabinoids to treat motor tics and to improve motor coordination in patients with TS. This evidence concerns the gene GPR55 and Timothy syndrome.