Recognizing that most corticotroph adenomas express CRH receptors (CRH-1R), Walia and colleagues observed that conjugation of 68Ga-DOTA to CRH (68Ga-CRH) yields a PET ligand with apparent high sensitivity and specificity for the detection of ACTH-secreting pituitary adenomas [15]. The gene discussed is CRH; the disease is ACTH-producing pituitary gland adenoma.