Transthyretin, a physiological protein synthesised by the liver, misfolds into insoluble B-pleated sheets and accumulates as amyloid fibrils in the extracellular space of the myocardium resulting in a specific cardiomyopathy (CM) that is characterised by myocardial thickening and stiffening [4]. This evidence concerns the gene TTR and cutaneous mastocytosis.