We first observed that stimulation of primary monocyte-derived macrophages with CoV2-AC, but not infection with SARS-CoV-2, reduced the expression of genes associated with alternative programming to tissue remodeling and secretion of immune-modulatory mediators such as CCL18, CD206 (also known as MRC1), MMP9, PPARG, and CD163 (Figure 2A). This evidence concerns the gene MMP9 and infection.