Agreeing with previous reports (Chu et al., 2020; Ren et al., 2020; Zhu et al., 2020), infection with SARS-CoV-2 for 48 hr induced caspase-3 and caspase-8 activation in immortalized simian kidney epithelial Vero CCL81 (Figure 1A) and human lung epithelial Calu-3 cell lines (Figure 1A and B). The gene discussed is CASP8; the disease is infection.