Caloric restriction extends lifespan and protects from tumorigenesis [77]PI3K/AKT/mTOR pathway is hyperactivated in various tumor types [172]Inhibition of mTOR has significant benefits as an anticancer therapy [104]Sirtuins act as tumor suppressors [81, 87, 88, 89, 90, 91]Sirtuins are mutated or deleted in various cancers [89, 92]. Here, PIK3CA is linked to cancer.