For instance, in the mouse models, MITF mutations induce defects in neural crest-derived melanocyte and retinal pigment epithelium differentiation, osteoclastogenesis, mast cell differentiation, and notch signaling that manifest phenotypically as changes in coat color, small eyes, osteopetrosis, and a reduction in NK cell, B cell, and macrophage numbers [66]. The gene discussed is MITF; the disease is osteopetrosis.