Coherently, a Drosophila melanogaster knockdown model for Mitf, the only fly orthologue of these transcription factors, shows autophagic defects and accumulation of autophagic substrate [22]; the activity of Mitf has also been linked to the autophagosomal defects observed in a fly neurodegeneration model of amyotrophic lateral sclerosis (ALS) [23]. The gene discussed is MITF; the disease is amyotrophic lateral sclerosis.