TFEB and neurodegenerative disease: Interestingly, the dysregulation of autophagy in neurodegenerative diseases may also present as an increase in autophagy or TFEB activation, as discussed in Section “.TFEB and Autophagy in Neurodegeneration” This suggests that special care must be taken when designing possible therapeutic approaches impacting these mechanisms, in order to preserve autophagy homeostasis, rather than pushing the autophagic machinery without considering possible undesired effects.