Many inflammatory mediators, like tumor necrosis factor (TNF-), nitric oxide (NO), prostaglandins, reactive oxygen species (ROS), leukotrienes, and enzymes (lipoxygenases, cyclooxygenases (COX-1 and COX-2), and phospholipases), play a key role in bone destruction and synovial membrane inflammation during the development of rheumatoid arthritis [12]. The gene discussed is TNF; the disease is rheumatoid arthritis.