MAPT and Alzheimer disease: Alzheimer’s disease (AD) is a common and irreversible neurodegenerative disorder associated with age and characterized by two main histological hallmarks: the accumulation of amyloid beta (Aβ) aggregated in extracellular senile plaques, and the hyperphosphorylation of Tau protein (pTau) forming intracellular neurofibrillary tangles (NFTs) [1].