Examination of results in animal and cellular models of AD mimicking familial forms of AD and in the brains of SAD patients, have then led to the hypothesis that impaired mitophagy is an important aspect of the disease, and could lie both upstream and downstream of Aβ and Tau in a vicious circle ultimately causing synaptic dysfunctions and cognitive deficits [9]. The gene discussed is MAPT; the disease is Alzheimer disease.