Interestingly, a molecular signature of impaired mitophagy was also reported in the peripheral fluids of AD patients as evidenced by a reduction of the autophagic ATG5 factor and of Parkin levels in the serum [26], and a decrease of Parkin alongside with an increase of PINK1 and LC3 mRNA levels in peripheral blood [27]. The gene discussed is PRKN; the disease is Alzheimer disease.