OPTN and Alzheimer disease: Other studies investigated the impact of PINK1 in a preclinical AD model, showing that intra-hippocampal stereotaxic injections of AAV2-hPINK1 in 6-month-old transgenic mice overexpressing hAPP bearing the Swedish and the Indiana (V717F) mutations triggered an induction of mitophagy via an upregulation of OPTN and NDP52 mitophagic receptors [13].