Multivariate Cox proportional regression analysis showed that IGFBP4 (HR = 0.252, 95% CI 0.122–0.517, P < 0.001) and TAGLN (HR = 0.155, 95% CI 0.089–0.269, P < 0.001) were significantly correlated with OS, whereas the sex (HR = 1.177, 95% CI 0.752–1.844, P = 0.476), age (HR = 0.894, 95% CI 0.585–1.365, P = 0.603), tumor size (HR = 1.165, 95% CI 0.776–1.750, P = 0.462), pathologic grade (HR = 1.012, 95% CI 0.791–1.295, P = 0.923), tumor metastasis (HR = 1.475, 95% CI 0.596–3.651, P = 0.400) and enneking stage (HR = 1.238, 95% CI 0.979–1.565, P = 0.075) have no correlation with OS (Table 3). The gene discussed is IGFBP4; the disease is neoplasm.