The lowest p-value associations for SNVs in the TOPMed WGS studies of fasting insulinadjBMI and type 2 diabetes for SNVs for our gene-traits were SPTY2D1 (p = 2 × 10–6), PHIP (p = 2 × 10–4), TSPO (p = 8 × 10–4) and TRPM3 (p = 8 × 10–7) for fasting insulinadjBMI, and TRMP3 (p = 2 × 10–3) for type 2 diabetes (Table S6). This evidence concerns the gene TSPO and type 2 diabetes mellitus.