This decreased periodontal inflammation in T2DM through dephosphorylation of colony‐stimulating factor 1 receptor at the Tyr807 site and other protein phosphatase substrates in the JAK1/STAT3 signaling pathway.190,194 PTPN2 blocked the process of macrophage inflammation by mediating p65/p38/STAT3 dephosphorylation in atherosclerosis.195 Overall, PTPN2 is considered an anti-inflammatory protein phosphatase that negatively moderates many inflammatory diseases. The gene discussed is STAT3; the disease is atherosclerosis.