PPP6C and psoriasis: PP6 dephosphorylated TAK1 at Thr187 to modulate TAK1-induced NF-κB activity.230 NF-κB pathway activation was prolonged in keratinocytes derived from keratinocyte-specific PP6c conditional knockout mice.231 A recent study reported that PP6 deficiency in keratinocytes led to psoriasis-like skin inflammation and promoted IL-6 production through endosomal self-RNA sensing by dendritic cells.232