PP2A also has a role in inflammatory diseases, including neurodegenerative diseases (particularly AD) and autoimmune diseases.10 PP2A participates in inflammation processes through its regulation of the TLR/NF-κB, MAPK and tristetraprolin signaling pathways10,124 and through its role in T cells125,126 or other cell types. This evidence concerns the gene PTPA and autoimmune disease.