A case report showed that a patient with Noonan syndrome-like symptoms and an SHP2 mutation showed an associated development of systemic lupus erythematosus (SLE), indicating the involvement of SHP2 in skin inflammation.90 Wang et al. also found increased activity of SHP2 in splenocytes from lupus-prone MRL/lpr mice or in peripheral blood mononuclear cells from patients with SLE. This evidence concerns the gene PTPN11 and Noonan syndrome.