One study found that PTPN14 mediated the dephosphorylation and restoration of vascular endothelial cadherin at adherens junctions in LPS-induced acute lung injury, indicating a role for PTPN14 in inflammation responses.196 In a mouse model of LPS- and D-GalN-induced acute liver failure, PTPN14 initiated a cytokine storm by promoting ubiquitination of a suppressor of cytokine signaling and its downstream NF-κB signaling.197 In summary, the limited evidence in inflammation-related diseases indicates that PTPN14 may have an important role in the immune response and other inflammatory diseases. Here, PTPN14 is linked to acute liver failure.