SHP1 shares a high homology with SHP2 and has been reported to play essential roles in immune and inflammatory signaling pathways.181 It is also involved in neutrophilic dermatosis,182 rheumatoid arthritis,183 allergic inflammation, and anaphylaxis,184,185 as well as TNFα-induced endothelial inflammation,186 through regulation of IL-1 α/IL-1 αR signaling, Src and Syk kinases, and MyD88 signaling in different immune cells and/or epithelial cell and stromal cells.187,188. The gene discussed is PTPN11; the disease is rheumatoid arthritis.