STAT3 and pulmonary fibrosis: SHP2 also activated fibroblast growth factor (FGF)/ Grb2-associated binder family proteins (Gab)/ERK signaling, which is required for the lung epithelial repair program.61 Bleomycin-induced lung fibrosis tissues also showed a marked activation of SHP2, STAT3, and suppressor of cytokine signaling 3 that was highly associated with pulmonary parenchymal lesions and collagen deposition.