PTPN11 and esophageal cancer: Recently, a new method called PROTAC was introduced for the specific degradation of SHP2.253 The first PROTAC molecule discovered to target SHP2 was SHP2-D26.261 This molecule rapidly reduced SHP2 protein levels by more than 95% in KYSE520 esophageal cancer cells and MV411 acute myeloid leukemia cells.