DUSP5 and osteoarthritis: DUSP5 was reported to inhibit interleukin-1β -induced chondrocyte inflammation and to ameliorate osteoarthritis by inhibiting the NF-κB and ERK signaling pathways in rats.219 Analogously, DUSP5 mediated the protective effects against a high glucose‐induced inflammatory response by reducing the production of ROS and inflammatory cytokines.220