IGHE and atopic eczema: These immunomodulatory characteristics could be further supported by long-term clinical improvements and decrease in serum total IgE levels lasting for more than 9 months observed in 2 out of 3 adult patients with severe atopic dermatitis who were followed up for more than 2 years after 8 intramuscular administrations of 50 mg autologous total IgG for 4 weeks.[24]