Then we checked each case and found that in four of 54 tested (HPB 115 treated with HLA‐C*03:04 peptides of HCC 25, HPB 117 treated with HLA‐C*03:02 peptides of HCC 217, HPB 118 treated with HLA‐A*11:01 peptide 6–10 of HCC 277, HPB 126 treated with HLA‐A*11:01 peptides of HCC 448), ICIs treatment had an effect of improving IFN‐γ CD107a and CD137 in CD8+ T cells, but the effect of IFN‐γ CD107a was limited (Figure 5B,C). Here, TNFRSF9 is linked to hepatocellular carcinoma.