The clinical characteristics of 27 patients (22 hepatocellular carcinoma (HCC), 3 intrahepatic cholangiocarcinoma (ICC), and 2 gallbladder cancer (GBC)) and top 20 high‐frequency neoantigen‐associated mutant genes in WGS analysis (including TP53 (43%), TTN (30%), MUC16 (24%), MUC4 (19%)) were shown (Figure 1B; and Table S1, Supporting Information). Here, MUC16 is linked to intrahepatic cholangiocarcinoma.