Furthermore, the multivariate cox regression analysis demonstrated the independent influence of CASC2 value (>0.35 vs. <0.35; hazard ratio [HR] = 0.068, 95% confidence interval [CI] = 0.016–0.292, P < 0.001) and age (<3.3 years old [mean value] vs. >3.3 years old; HR = 2.806, 95% CI = 1.240–6.394, P < 0.001) on the poor prognosis of children with severe pneumonia (Table 3). The gene discussed is CASC2; the disease is pneumonia.