On the other hand, in transcriptional misregulation in the cancer signaling pathway, only MYCN expression was notably decreased, and the expression of 20 genes, including GADD45A, CXCL8, JMJD1C, RUNX1, and H3C14, was significantly increased in NHEKs upon HPV8 E7 expression (Supplementary Figure S2B; Figures 3D,E). Here, GADD45A is linked to cancer.