The two most significant eQTM mediators of neighborhood socioeconomic disadvantage on HDL-C were cg03254336, corresponding to expression of transcription factor 7-like 2 (TCF7L2), a major genetic risk factor for type 2 diabetes, and cg10699171, corresponding to expression of RHO family interacting cell polarization regulator 2 (FAM65B). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.