PACS2 and metabolic disease: Other highly ranked CpGs in our study are in the gene bodies of solute carrier 25A10 (SLC25A10), encoding a protein that increases lipid accumulation in adipose tissues (85), and phosphofurin acidic cluster sorting protein 2 (PACS2), which encodes a mitochondrial-associated membrane protein important for cellular homeostasis and implicated in obesity and other metabolic disorders including diabetes and metabolic syndrome (86).