O'Connor et al. showed that CgA was increased by 117% (p < 0.001) in HT patients, whereas Cts reduced by 15% (p = 0.036), which suggests diminished conversion of CgA to Cts in HT (normotensives' CgA/Cts ratio of 4.5 ± 0.2 vs. 5.9 ± 0.4 in HT patients, p = 0.005) (61). The gene discussed is CGA; the disease is hematocrit.