Concerning HF, Dan Zhu et al. showed that the higher the severity stage of HF (according to the American Heart Association, AHA), the lower the Cts level, and that Cts might be a better predictive factor for stage B HF than brain natriuretic peptide, a marker commonly used in clinical practice for HF diagnosis and severity assessment (76). This evidence concerns the gene NPPB and hydrops fetalis.