SLC9A3 and cystic fibrosis: In addition, the PGE1 (prostaglandin E1) analogue lubiprostone, which can induce signaling cascades mediated by prostaglandin receptors EP1 and EP4 and primarily stimulates Cl− secretion via CFTR while at the same time suppressing the incorporation of NHE3 into the brush border membrane (Jakab et al., 2012), may be used to attenuate constipation in CF patients (Tan et al., 2021).