Apart from that, NHE3 cooperates with the Cl−/HCO3− exchanger SLC26A3, also known as DRA (downregulated in adenoma), to mediate the absorption of Na+ and Cl− (Höglund et al., 1996; Melvin et al., 1999; Jacob et al., 2002). Here, SLC9A3 is linked to adenoma.