Second, abnormally correlated activity of GPe neurons and STN neurons in PD state (Mallet et al., 2008a) suggests that NMDAR-dependent synaptic plasticity may play the role of classical coincidence detectors in this process where parkinsonian GPe- STN activity would both promote and be promoted by this form of plasticity (Chu et al., 2017, 2015). Here, GYPE is linked to Parkinson disease.