PRKN and Parkinson disease: In this study, a genetic model of misfolded α-synuclein was used but the effects of low dose DSS should be studied in other PD models such as transgenic mice that overexpress human α-synuclein with a PD-associated mutation (A53T) (95), Parkin knockout mice (96, 97), and the mitopark mouse model (98, 99) could all be considered for future studies.