To further reinforce DX308's ability to modulate retinoid biopathways in multiple donors and pathologies, the expression of three retinoid‐responsive genes (CYP26A1, KRT10 and HBEGF) were investigated in healthy and keratinization disorder (including DD, RXLI and LI) RHE and monolayer KCs. This evidence concerns the gene HBEGF and keratinization disease.