Serum LH levels are increased in PCOS because of disrupted hypothalamic-pituitary axis that activates PI3K/Akt pathway causing the overexpression of ovarian CYP17A1 gene along with 17-α hydroxylase enzyme levels, which is used in the reaction to synthesize the androgen from progesterone [45]. Here, CYP17A1 is linked to polycystic ovary syndrome.