Serum LH levels are increased in PCOS because of disrupted hypothalamic-pituitary axis that activates PI3K/Akt pathway causing the overexpression of ovarian CYP17A1 gene along with 17-α hydroxylase enzyme levels, which is used in the reaction to synthesize the androgen from progesterone [45]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.