The inflammatory mediators (interleukin IL-6, IL-1, tumor necrosis factor TNF) released after severe infection, activating the IF-IL-6 site on the antimicrobial peptide LL-37 by Kinase/signal and transcription activator (JAK/STAT) pathway or Ras-dependent mitogen-activated protein kinase (MAPK) pathway, so significantly increasing the expression of LL-37 (35). This evidence concerns the gene TNF and infection.