RIMS2 and neoplasm: Tumors L39 and L36 had concurrent mutations in TP53 with similar, low VAFs while tumor L01 carried mutations in KMT2C, FBXW7, RIMS2 and NF1 with VAF in a range of 7-17%; in these cases, KMT2C mutations were probably clonal and their VAF reflected lower tumor content in the sample.