In addition, a variety of genes such as phospholipase C epsilon (PLCE1) (25), ubiquitin specific peptidase 26 (USP26) (26), ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) (27), Deubiquitinating enzyme PSMD14 (28, 29), polycomb chromobox proteins 8 (CBX8) (30), glioma-associated oncogene homolog 1(GLI1) (31), Notch-1 (32), SPSB3 (33) and T−cell immunoglobulin and mucin domain−containing protein−3 (TIM−3) (34) can participate in the progression of esophageal cancer by regulating the expression or stability of Snail. Here, SPSB3 is linked to esophageal cancer.