1) The effect of neoadjuvant therapy in node-positive HER2+ BC: one of the clinical response criteria in the NOAH trial was complete response (in breast tissue and axillary nodes), obtained in 38% of patients treated with trastuzumab versus placebo; this concept was reinforced in the Neosphere trial, which provided new insights into the association between total pCR and long-term outcomes. The gene discussed is ERBB2; the disease is breast cancer.