ERBB2 and breast cancer: Further therapeutic strategies have therefore been explored (4), using other anti-HER2 drugs such as pertuzumab, a monoclonal antibody that blocks another extracellular subdomain of the HER2 receptor, the antibody–drug conjugate trastuzumab–emtansine (T-DM1), and the irreversible pan-HER2 inhibitor neratinib in the neoadjuvant or adjuvant setting for the management of early HER2-positive BC (5).