TGFB1 and familial pancreatic carcinoma: Approximately 32 recurrently mutated genes in pancreatic cancer that aggregate into 10 core pathways have been reported: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signaling, G1/S transition, SWI-SNF, chromatin modification, DNA repair, and RNA processing (3).