For instance, DDR1, discoidin domain receptor 1, a receptor for collagens in the extracellular matrix (ECM) of tumors has recently emerged as a potentially targetable gene against KRAS-mutant lung adenocarcinoma, and DDR1 targeting has also been identified to be beneficial against metastatic colon cancers (66–68). This evidence concerns the gene KRAS and lung adenocarcinoma.