Additionally, correlation analysis was performed to evaluate associations between the mRNA expression of a selected panel of genes, with mRNA expression of DDR1 and KRAS in patient datasets of COAD, GBM, and Pan-Cancer revealed i) DDR1 to positively correlate with downstream mediators of KRAS signaling (BRAF, PIK3CA, and MTOR) in both tumors COAD and GBM and with EGFR, ERBB2, BRAF, BCR, SOX9, VANGL2, and CDH1 in Pan-Cancer; and ii) KRAS to correlate with genes BRAF, PIK3CA, APC, and CTNNB1 in Pan-Cancer (Supplementary Figure 6A) (Excel sheet 2, sub-sheet S2.3–S2.5). The gene discussed is PIK3CA; the disease is colon adenocarcinoma.