Mutations in WNT regulators, such as loss-of-function mutations in adenomatous polyposis coli (APC) gene, are the prime triggers for CRC and activating mutations in KRAS (Kirsten’s rat sarcoma virus oncogene), and its downstream effectors (like PI3K and BRAF) serve as subtype-specific oncogenic drivers. The gene discussed is APC; the disease is colorectal carcinoma.