Our genomic analysis revealed ERBB2, DDR1, BCR, and LYN (Src kinase) genes for WNT regulation (LGR5) were upregulated in COAD and DDR1 to positively correlate with BCR, EGFR, and ERBB2 in Pan-Cancer, all of which can emphasize the possible synergy of EGFR/ERBB2 inhibition with inhibitors of DDR1-BCR-ABL signaling. This evidence concerns the gene LGR5 and polyarteritis nodosa.