To further investigate the prognostic analysis of three genes (FCGR2A, PDE3A, and EPPK1) in the prognostic model, Kaplan–Meier analysis indicated that three genes were associated with patient survival rate;PDE3A and EPPK1 were negatively correlated with survival of melanoma patients; however, FCGR2A was positively correlated with melanoma patient survival (Figure 7D and Supplementary Figure 3). This evidence concerns the gene EPPK1 and melanoma.