Based on the findings that LINC00665 was primarily distributed in the cytoplasm of NSCLC cells, LINC00665 was found to recruit EZH2 to the CDKN1C promoter region to facilitate the demethylation of histone H3K27 and inhibit CDKN1C transcription. This evidence concerns the gene CDKN1C and non-small cell lung carcinoma.