-Inhibiting the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages in multiple sclerosis-Inhibiting LPS-induced NO and production of pro-inflammatory cytokines by inhibiting the NF-kB activation in BV2 microglial cells in multiple sclerosis. Here, PTGS2 is linked to multiple sclerosis.