TNF and arthritic joint disease: -Reduced levels of pro-inflammatory cytokines (TNF-α and IL-1β) in the serum and synovial fluid in adjuvant-induced arthritis in rats-Regulates the cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, leading to the suppression of various pro-inflammatory mediators, including MMP9 and MMP13 in arthritis-Inhibition of IL-12 signaling pathway in T cells in multiple sclerosis.