NF-κB, NF-κB/TNF-α/vascular cell adhesion molecule-1, and TGF-β1/α-smooth muscle/vimentin signaling pathways induced by TNFs and TLR4 in rheumatoid arthritis-Downregulation of p38 MAPK and NF-κB signaling pathways in neuroinflammation. The gene discussed is TLR4; the disease is rheumatoid arthritis.