-Suppression of the levels of IL-4, IL-5, IL-13, and IgE levels in serum in mouse model for asthma-Increase the Treg cells production of interleukin IL-10, transforming growth factor (TGF-β), reduction in production of IL-17 and IL-6, decrease in the percentages of Th17 cells, % of Treg cells in the spleen and lymph nodes, reduces ROR-γt factor expression, but enhanced Foxp3 expression in mouse model for multiple sclerosis. The gene discussed is IGHE; the disease is multiple sclerosis.