It has been revealed in a GCPDX that a complex between ISL1 and SETD7 (a histone H3K4-specific methyltransferase) can directly bind to ZEB1(Key regulator of epithelial-mesenchymal transition (EMT)) promoter to promote the molecular mechanism of GC metastasis, which demonstrated that ISL1 may be a potential prognostic biomarker for GC (114). This evidence concerns the gene ISL1 and gastric cancer.