IFNG and neoplasm: During the early phase of the development of a murine sarcoma induced by 3-methylcholanthrene, neutrophils amplified the production of IL12 by macrophages, which in turn drove the release of the interferon-gamma (IFNγ) by a subset of unconventional T cells, establishing an anti-tumor immunity that led to a reduced incidence of sarcoma (46).