NFKB1 and neoplasm: For example, chemotherapy may also induce DNA damage in stromal cells, resulting in the activation of NF-κB contributing to therapeutic resistance (14), and radiotherapy may affect the tumor vasculature promoting cancer cell survival and radio-resistance (15); as well, specific therapies can show a synergistic effect by promoting immunogenic cell death and enhancing T cell-dependent anti-tumor immunity (16, 17).