As well, the genetic inactivation of the atypical chemokine receptors 2 (ACKR2), a scavenger for inflammatory chemokines and hence a negative regulator of inflammation (expressed in hematopoietic precursors), resulted in the release from the BM neutrophils showing higher anti-metastatic activity in mice orthotopically transplanted with 4T1 mammary carcinoma or intravenously injected with B16F10 melanoma (50). The gene discussed is ACKR2; the disease is breast carcinoma.