The VEGF/VEGFR, the angiopoietins (ANGPT) and their tyrosine kinase receptors (Tie2/Tek), or molecules mediating tumor angiogenesis, like the fibroblast growth factor (bFGF/FGF2) and platelet-derived growth factor-B (PDGF-B), have been the main targets. The gene discussed is FGF2; the disease is neoplasm.