Interestingly, PI3Kγ is a key regulator of TAM-mediated immunosuppression (256), and its selective inhibition increases MHC-II and IL12 expression and decreases IL10 in TAMs; as well as helping to overcome resistance to ICI, reshaping the TME and promoting CD8+ T cell recruitment and tumor regression (256, 257). Here, CD8A is linked to neoplasm.