There are currently inconsistent reports regarding the association between the expression status of ERs and EGFR mutation in lung adenocarcinoma, with some studies suggesting that ERα overexpression correlated with EGFR mutation, and some research reporting that ER βoverexpression correlated with EGFR mutation, whereas, another study reported no association between the expression status of ERα, ERβ and EGFR mutations(s). This evidence concerns the gene ESR1 and lung adenocarcinoma.