The positive correlation between expressions of ERα and ERβ was in agreement with previous report in lung adenocarcinomas (15), but contradicted with the study reporting no correlation was found between ERα and ERβ expressions in lung cancer (16).This difference in correlation between expressions of ERα and ERβ could be caused by different histology types researched and different antibodies to ERα and ERβ by different manufacturers (17). The gene discussed is ESR1; the disease is lung carcinoma.