Another study found that miR-16 can inhibit PCa cell growth by regulating CDK1 and CDK2, two cell cycle regulatory proteins,300 miR-15a and miR-16-1 have also been shown to affect the survival, growth, and metastasis of PCa cells by triggering CCND1 (encoding cyclin D1) and WNT3A.301. This evidence concerns the gene CDK2 and posterior cortical atrophy.