α-Synuclein has been the focus of intense research efforts due to its strong coupling with Parkinson’s disease (PD) and other synucleinopathies: it is a component of the Lewy bodies occurring in the diseased brain, and mutations in α-synuclein cause rare familial variants of PD (Simon et al., 2020). The gene discussed is SNCA; the disease is synucleinopathy.