CHMP5 and COVID-19: Moreover, the currently reported 17 non-synonymous mutations that happened in the ORF1ab, ORF7a, ORF8, and spike genes of the SARS-CoV-2 genome (Tortorici et al., 2019) in a family cluster of COVID-19 patients supported the hypothesis that the viral mutations could have occurred during person-to-person transmission.